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1.

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

Sharabi, Kfir; Lin, Hua; Tavares, Clint D J; Dominy, John E; Camporez, Joao Paulo; Perry, Rachel J; Schilling, Roger; Rines, Amy K; Lee, Jaemin; Hickey, Marc; Bennion, Melissa; Palmer, Michelle; Nag, Partha P; Bittker, Joshua A; Perez, José; Jedrychowski, Mark P; Ozcan, Umut; Gygi, Steve P; Kamenecka, Theodore M; Shulman, Gerald I; Schreiber, Stuart L; Griffin, Patrick R; Puigserver, Pere.

Cell ; 169(1): 148-160.e15, 2017 03 23.

Artículo en Inglés | MEDLINE | ID: mdl-28340340

2.

Inflammation Improves Glucose Homeostasis through IKKß-XBP1s Interaction.

Liu, Junli; Ibi, Dorina; Taniguchi, Koji; Lee, Jaemin; Herrema, Hilde; Akosman, Bedia; Mucka, Patrick; Salazar Hernandez, Mario Andres; Uyar, Muhemmet Fatih; Park, Sang Won; Karin, Michael; Ozcan, Umut.

Cell ; 167(4): 1052-1066.e18, 2016 11 03.

Artículo en Inglés | MEDLINE | ID: mdl-27814504

3.

Treatment of obesity with celastrol.

Liu, Junli; Lee, Jaemin; Salazar Hernandez, Mario Andres; Mazitschek, Ralph; Ozcan, Umut.

Cell ; 161(5): 999-1011, 2015 May 21.

Artículo en Inglés | MEDLINE | ID: mdl-26000480

4.

Mom's milk molds neural wiring for metabolism.

Cakir, Isin; Ozcan, Umut.

Cell ; 156(3): 396-7, 2014 Jan 30.

Artículo en Inglés | MEDLINE | ID: mdl-24485448

5.

Mitofusins: mighty regulators of metabolism.

Ozcan, Umut.

Cell ; 155(1): 17-8, 2013 Sep 26.

Artículo en Inglés | MEDLINE | ID: mdl-24074856

6.

XBP1s Is an Anti-lipogenic Protein.

Herrema, Hilde; Zhou, Yingjiang; Zhang, Dongyan; Lee, Justin; Salazar Hernandez, Mario Andres; Shulman, Gerald I; Ozcan, Umut.

J Biol Chem ; 291(33): 17394-404, 2016 08 12.

Artículo en Inglés | MEDLINE | ID: mdl-27325692

7.

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

Ozcan, Umut; Ozcan, Lale; Yilmaz, Erkan; Düvel, Katrin; Sahin, Mustafa; Manning, Brendan D; Hotamisligil, Gökhan S.

Mol Cell ; 29(5): 541-51, 2008 Mar 14.

Artículo en Inglés | MEDLINE | ID: mdl-18342602

8.

Unfolded protein response signaling and metabolic diseases.

Lee, Jaemin; Ozcan, Umut.

J Biol Chem ; 289(3): 1203-11, 2014 Jan 17.

Artículo en Inglés | MEDLINE | ID: mdl-24324257

9.

IRS1Ser³°7 phosphorylation does not mediate mTORC1-induced insulin resistance.

Herrema, Hilde; Lee, Jaemin; Zhou, Yingjiang; Copps, Kyle D; White, Morris F; Ozcan, Umut.

Biochem Biophys Res Commun ; 443(2): 689-93, 2014 Jan 10.

Artículo en Inglés | MEDLINE | ID: mdl-24333417

10.

Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.

Guan, Dongxian; Men, Yuqin; Bartlett, Alexander; Hernández, Mario Andrés Salazar; Xu, Jie; Yi, Xinchi; Li, Hu-Song; Kong, Dong; Mazitschek, Ralph; Ozcan, Umut.

Cell Metab ; 36(4): 857-876.e10, 2024 Apr 02.

Artículo en Inglés | MEDLINE | ID: mdl-38569472

11.

Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity.

Park, Sang Won; Zhou, Yingjiang; Lee, Jaemin; Lee, Justin; Ozcan, Umut.

Proc Natl Acad Sci U S A ; 107(45): 19320-5, 2010 Nov 09.

Artículo en Inglés | MEDLINE | ID: mdl-20974941

12.

Antisense-mediated senseful regulation of orchestrated metabolic response.

Ozcan, Umut.

Cell Chem Biol ; 29(4): 539-540, 2022 04 21.

Artículo en Inglés | MEDLINE | ID: mdl-35452620

13.

FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity.

Herrema, Hilde; Guan, Dongxian; Choi, Jae Won; Feng, Xudong; Salazar Hernandez, Mario Andres; Faruk, Farhana; Auen, Thomas; Boudett, Eliza; Tao, Rongya; Chun, Hyonho; Ozcan, Umut.

Cell Metab ; 34(7): 1004-1022.e8, 2022 07 05.

Artículo en Inglés | MEDLINE | ID: mdl-35793654

14.

Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.

El Manaa, Wejdane; Duplan, Eric; Goiran, Thomas; Lauritzen, Inger; Vaillant Beuchot, Loan; Lacas-Gervais, Sandra; Morais, Vanessa Alexandra; You, Han; Qi, Ling; Salazar, Mario; Ozcan, Umut; Chami, Mounia; Checler, Frédéric; Alves da Costa, Cristine.

Autophagy ; 17(12): 4363-4385, 2021 12.

Artículo en Inglés | MEDLINE | ID: mdl-34030589

15.

Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight.

Feng, Xudong; Guan, Dongxian; Auen, Thomas; Choi, Jae Won; Salazar-Hernandez, Mario Andres; Faruk, Farhana; Copps, Kyle D; Ozcan, Umut.

Sci Rep ; 9(1): 12809, 2019 09 05.

Artículo en Inglés | MEDLINE | ID: mdl-31488870

16.

IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects.

Feng, Xudong; Guan, Dongxian; Auen, Thomas; Choi, Jae Won; Salazar Hernández, Mario Andrés; Lee, Jaemin; Chun, Hyonho; Faruk, Farhana; Kaplun, Esther; Herbert, Zachary; Copps, Kyle D; Ozcan, Umut.

Nat Med ; 25(4): 575-582, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-30833749

17.

Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFß1.

Gao, Pan; Li, Liliang; Yang, Liu; Gui, Dingkun; Zhang, Jiarong; Han, Junfeng; Wang, Jiajia; Wang, Niansong; Lu, Junxi; Chen, Suzhen; Hou, Liping; Sun, Honglin; Xie, Liping; Zhou, Jian; Peng, Chao; Lu, Yan; Peng, Xuemei; Wang, Cunchuan; Miao, Ji; Ozcan, Umut; Huang, Yu; Jia, Weiping; Liu, Junli.

Sci Transl Med ; 11(510)2019 09 18.

Artículo en Inglés | MEDLINE | ID: mdl-31534017

18.

Melanin concentrating hormone is a novel regulator of islet function and growth.

Pissios, Pavlos; Ozcan, Umut; Kokkotou, Efi; Okada, Terumasa; Liew, Chong Wee; Liu, Siming; Peters, Jennifer N; Dahlgren, Gabriella; Karamchandani, Jason; Kudva, Yogish C; Kurpad, Amarnath J; Kennedy, Robert T; Maratos-Flier, Eleftheria; Kulkarni, Rohit N.

Diabetes ; 56(2): 311-9, 2007 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-17259374

19.

PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism.

Lee, Jaemin; Salazar Hernández, Mario Andrés; Auen, Thomas; Mucka, Patrick; Lee, Justin; Ozcan, Umut.

Mol Metab ; 7: 119-131, 2018 01.

Artículo en Inglés | MEDLINE | ID: mdl-29129613

20.

Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.

Hennige, Anita M; Burks, Deborah J; Ozcan, Umut; Kulkarni, Rohit N; Ye, Jing; Park, Sunmin; Schubert, Markus; Fisher, Tracey L; Dow, Matt A; Leshan, Rebecca; Zakaria, Mark; Mossa-Basha, Mahmud; White, Morris F.

J Clin Invest ; 112(10): 1521-32, 2003 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-14617753

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